Bactrian Camel (Camelus bactrianus) Milk Exosomes Promote Glucose Consumption in L6 Cells

Background: Camel milk can treat diabetes, but the exact anti-diabetes components of camel are still unclear. It is not clear whether exosomes regulate glucose metabolism. Therefore, aim this study was to determine promote consumption in L6 cells. Methods: were isolated by ultracentrifugation and identified transmission electron microscopy (TEM). Cell Counting Kit-8(CCK-8) assay used detect effects different concentrations on viability Glucose oxidase activity effect RNA sequencing differentially expressed genes enriched pathways cells treated with exosomes. Result: The size 30-100 nm TEM. 3-12 ng/uL had no significant cell (P greater than 0.05). 6-24 significantly increase less A total 401 (DEGs) identified. Gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analyses downregulated suggested inhibition mitochondrial respiratory chain complex I. may inhibiting